Accuracy of modification of diet for renal disease and Cockcroft-Gault equations as compared to the radioisotope double sample method: A study in patients with acute renal failure
Authors
Abstract:
Introduction: We intended to assess the accuracy of re-expressed Modification of Diet for Renal Disease (MDRD) and Cockcroft-Gault (CG) equations to estimate glomerular filtration rate (GFR) in chronic kidney disease in two different etiologies of acute renal failure (ARF): acute tubular necrosis (ATN) and acute glomerulonephritis (AGN). Methods: Patients admitted for ARF or the patients complicated with ARF during the course of their hospitalization were enrolled to the study (n=21; 14 females and 7 males; 11 ATN and 12 AGN). When the plasma creatinine reached a steady state (DPSM) using 99mTc-DTPA. GFR was also estimated by MDRD (GFRMDRD) and CG (GFRCG) equations. Results: The patients aged 44.8±19.5 years and weighted 67.8±10.7kg. GFRDPSM (32.9±14.7 ml/min) was statistically different from the GFRMDRD (11.6±8.2 ml/min; pCG was lower than GFRDPSM in patients with either ATN (16.5±12.5ml/min and pDPSM and GFRMDRD (r=0.34; p=0.13) but GFRDPSM and GFRCG values were correlated (r=0.48; p=0.03). Out of subjects with GFRDPSM >30, 92.3% had GFRMDRDCG Conclusion: Our results indicate that MDRD and CG equations were substantially inaccurate in patients with ARF. More precise methods of GFR evaluation is recommended in these patients.
similar resources
accuracy of modification of diet for renal disease and cockcroft-gault equations as compared to the radioisotope double sample method: a study in patients with acute renal failure
introduction: we intended to assess the accuracy of re-expressed modification of diet for renal disease (mdrd) and cockcroft-gault (cg) equations to estimate glomerular filtration rate (gfr) in chronic kidney disease in two different etiologies of acute renal failure (arf): acute tubular necrosis (atn) and acute glomerulonephritis (agn). methods: patients admitted for arf or the patients compl...
full textPredictive performance of the modification of diet in renal disease and Cockcroft-Gault equations for estimating renal function.
Recent recommendations emphasize the need to assess kidney function using creatinine-based predictive equations to optimize the care of patients with chronic kidney disease. The most widely used equations are the Cockcroft-Gault (CG) and the simplified Modification of Diet in Renal Disease (MDRD) formulas. However, they still need to be validated in large samples of subjects, including large no...
full textEstimating glomerular filtration rate: Cockcroft-Gault and Modification of Diet in Renal Disease formulas compared to renal inulin clearance.
BACKGROUND AND OBJECTIVES Evaluation of renal function by estimation of the glomerular filtration rate (GFR) is very important for the diagnosis and treatment of patients with chronic kidney disease (CKD). The Cockcroft-Gault (CG) and Modification of Diet in Renal Disease (MDRD) formulas are the most commonly used estimations. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Estimated GFR values...
full textEstimating Glomerular Filtration Rate in Black South Africans Using the Modification of Diet in Renal Disease and Cockcroft-Gault Equations
BACKGROUND: The 4-variable Modification of Diet in Renal Disease (4-v MDRD) and Cockcroft-Gault (CG) equations are commonly used for estimating glomerular filtration rate (GFR); however, neither of these equations has been validated in an indigenous African population. The aim of this study was to evaluate the performance of the 4-v MDRD and CG equations for estimating GFR in black South Africa...
full textComparison of the Chronic Kidney Disease Epidemiology Collaboration, the Modification of Diet in Renal Disease study and the Cockcroft-Gault equation in patients with heart failure
BACKGROUND It is unknown how the creatinine-based renal function estimations differ for dose adjustment cut-offs and risk prediction in patients with heart failure. METHOD AND RESULTS The renal function was similar with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) (median 59 mL/min/1.73 m2, IQR 42 to 77) and Modification of Diet in Renal Disease Study (MDRD) (59 mL/min/1.73...
full textGlomerular filtration rate estimation using the Cockcroft-Gault and Modification of Diet in Renal Disease formulas for digoxin dose adjustment in patients with heart failure
OBJECTIVE The aim of this study was to compare the estimated glomerular filtration rate (GFR) using the Cockcroft-Gault and the 4-, 5-, and 6-variable Modification of Diet in Renal Disease (MDRD) formulas for digoxin dose adjustment. METHODS Steady-state serum digoxin concentrations were determined in 100 patients with heart failure and normal to severely impaired renal function. Total cleara...
full textMy Resources
Journal title
volume 22 issue 1
pages 23- 28
publication date 2014-01-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023